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  1. The genetic architecture responsible for chronic kidney disease (CKD) remains incompletely described. The Oligosyndactyly (Os) mouse models focal and segmental glomerulosclerosis (FSGS), which is associated with ...

    Authors: Ashraf El-Meanawy, Jeffery R Schelling, Sudha K Iyengar, Patrick Hayden, Shrinath Barathan, Katrina Goddard, Fatima Pozuelo, Essam Elashi, Viji Nair, Matthias Kretzler and John R Sedor
    Citation: BMC Nephrology 2012 13:61
  2. Predialysis hemoglobin (Hb) may overestimate the true erithropoiesis-stimulating agents (ESA) requeriments. We tested whether predialysis Hb is a reliable predictor of the postdialysis level to better control ...

    Authors: Nieves Castillo, Patricia García-García, Antonio Rivero, Alejandro Jiménez-Sosa, Manuel Macía, María Adela Getino, María Luisa Méndez, Javier García-Pérez and Juan F Navarro-González
    Citation: BMC Nephrology 2012 13:60
  3. Chronic kidney disease(CKD) has been proposed as a risk factor for cardiovascular disease (CVD). There is conflicting evidence among community based studies regarding the association between CKD and CVD. Furth...

    Authors: Farhad Hosseinpanah, Maryam Barzin, Hosein Aghayan Golkashani, Amir A Nassiri, Farhad Sheikholeslami and Fereidoun Azizi
    Citation: BMC Nephrology 2012 13:59
  4. Estimated glomerular filtration rate (eGFR) levels have been shown to predict atherosclerotic vascular disease hospitalization and mortality. We sought to investigate the role of renal function in the predicti...

    Authors: Joshua R Lewis, Wai Lim, Satvinder S Dhaliwal, Kun Zhu, Ee Mun Lim, Peter L Thompson and Richard L Prince
    Citation: BMC Nephrology 2012 13:58
  5. In addition to its canonical role in musculoskeletal health, several reports have demonstrated that serum vitamin D level may influence kidney function. However, the effect of pretransplant serum vitamin D lev...

    Authors: Hyunwook Kim, Shin-Wook Kang, Tae-Hyun Yoo, Myoung Soo Kim, Soon Il Kim, Yu Seun Kim and Kyu Hun Choi
    Citation: BMC Nephrology 2012 13:22
  6. Indigenous peoples worldwide are experiencing elevated rates of type 2 diabetes and its complications. To better understand the disproportionate burden of diabetic end stage renal disease (ESRD) among Canadian...

    Authors: Roland F Dyck, Mariam Naqshbandi Hayward and Stewart B Harris
    Citation: BMC Nephrology 2012 13:57
  7. Patients with chronic HCV infection have increased liver iron. Recently identified protein hepcidin synthesized in the liver, is thought to be a key regulator for iron homeostasis and is induced by infection a...

    Authors: Yasar Caliskan, Berna Yelken, Abdullah Ozkok, Numan Gorgulu, Halil Yazici, Aysegul Telci and Alaattin Yildiz
    Citation: BMC Nephrology 2012 13:56
  8. Low 25-hydroxy vitamin D (25(OH)D) levels have been associated with an increased risk of albuminuria, however an association with glomerular filtration rate (GFR) is not clear. We explored the relationship bet...

    Authors: Matthew J Damasiewicz, Dianna J Magliano, Robin M Daly, Claudia Gagnon, Zhong X Lu, Peter R Ebeling, Steven J Chadban, Robert C Atkins, Peter G Kerr, Jonathan E Shaw and Kevan R Polkinghorne
    Citation: BMC Nephrology 2012 13:55
  9. Kidney disease is the 9th leading cause of death in Singapore. While preventive effects have focused on early detection and education, little is known about the knowledge level of chronic kidney disease (CKD) ...

    Authors: Wai Leng Chow, Veena D Joshi, Aung Soe Tin, Saskia van der Erf, Jeremy Fung Yen Lim, Teck Sin Swah, Stephanie Swee Hong Teo, Paul Soo Chye Goh, Gilbert Choon Seng Tan, Crystal Lim and Terence Yi-shern Kee
    Citation: BMC Nephrology 2012 13:54
  10. Tacrolimus (FK506) is associated with renal fibrosis in long-term use. Mycophenolatemofetil (MMF) can also inhibit or attenuate the progression of renal fibrosis. This study aimed to determine the different ef...

    Authors: Lei Luo, Zhaolin Sun, Weidong Wu and Guangheng Luo
    Citation: BMC Nephrology 2012 13:53
  11. Long term longitudinal data are scarce on epidemiological characteristics and patient outcomes in patients on maintenance dialysis, especially in Switzerland. We examined changes in epidemiology of patients un...

    Authors: Petra Rhyn Lehmann, Manon Ambühl, Domenica Corleto, Richard Klaghofer and Patrice M Ambühl
    Citation: BMC Nephrology 2012 13:52
  12. Acute worsening of renal function, an independent risk factor for adverse outcomes in acute decompensated heart failure (ADHF), occurs as a consequence of new onset kidney injury (AKI) or acute deterioration o...

    Authors: Qiugen Zhou, Chunmei Zhao, Di Xie, Dingli Xu, Jianping Bin, Pingyan Chen, Min Liang, Xun Zhang and Fanfan Hou
    Citation: BMC Nephrology 2012 13:51
  13. Adequate anticoagulation is prerequisite for effective hemodialysis to prevent clotting in the extracorporeal circuit. We aimed providing first data on the efficacy and safety of the low-molecular-weight hepar...

    Authors: Oliver Dorsch, Detlef H Krieter, Horst-Dieter Lemke, Stefan Fischer, Nima Melzer, Christian Sieder, Peter Bramlage and Job Harenberg
    Citation: BMC Nephrology 2012 13:50
  14. Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone that is secreted from bone and serum level increases as renal function declines. Higher levels of FGF23 are associated with increased mortality in ...

    Authors: Inger H Bleskestad, Harald Bergrem, Anders Hartmann, Kristin Godang and Lasse G Gøransson
    Citation: BMC Nephrology 2012 13:49
  15. We investigated 1) the frequency of hypertension in patients with type 2 diabetes graded by the new classification of chronic kidney disease (CKD) reported by the Kidney Disease: Improving Global Outcomes (KDI...

    Authors: Hiroyuki Ito, Mizuo Mifune, Mariko Abe, Koshiro Oshikiri, Shinichi Antoku, Yuichiro Takeuchi, Michiko Togane, Shigenori Ando and Emiko Tsugami
    Citation: BMC Nephrology 2012 13:48
  16. Scleroderma renal crisis is an important complication of scleroderma (systemic sclerosis) that is associated with significant morbidity and mortality. On the other hand, hyponatremia has never been reported in...

    Authors: Hirotaka Fukasawa, Ryuichi Furuya, Sayaka Ishigaki, Naoko Kinoshita, Shinsuke Isobe and Yoshihide Fujigaki
    Citation: BMC Nephrology 2012 13:47
  17. Neutrophil gelatinase associated lipocalin (NGAL) is a highly predictive biomarker of acute kidney injury. To understand the role of NGAL in renal injury during sepsis, we investigated the temporal changes and...

    Authors: Mei Han, Ying Li, Maodong Liu, Yingmin Li and Bin Cong
    Citation: BMC Nephrology 2012 13:25
  18. Common variable immunodeficiency (CVID) is a disorder characterized by hypogammaglobulinemia without a known predisposing cause.

    Authors: Kenji Tsuji, Haruhito Adam Uchida, Tetsuichirou Ono, Tatsuyuki Inoue, Katsuji Shinagawa, Shinji Kitamura, Yohei Maeshima, Hitoshi Sugiyama and Hirofumi Makino
    Citation: BMC Nephrology 2012 13:46
  19. The main hypothesis of this study is that patients having regular conventional haemodialysis (HD) will have a smaller decline in cardiac systolic function by using cooler dialysate. Cooler dialysate may also b...

    Authors: Aghogho Odudu, Mohamed Tarek Eldehni, Apostolos Fakis and Christopher William McIntyre
    Citation: BMC Nephrology 2012 13:45
  20. Renal evaluation studies are rare in American Cutaneous Leishmaniasis (ACL). The aim of this study is to investigate whether specific treatment reverts ACL-associated renal dysfunction.

    Authors: Rodrigo A Oliveira, Cláudio G Lima, Rosa Ms Mota, Alice Mc Martins, Talita R Sanches, Antônio C Seguro, Lúcia C Andrade, Geraldo B Silva Junior, Alexandre B Libório and Elizabeth F Daher
    Citation: BMC Nephrology 2012 13:44
  21. Patients with end-stage renal disease (ESRD) are at a higher risk for chronic hepatitis, liver cirrhosis (LC) and mortality than the general population. Optimal modalities of renal replacement therapy for ESRD...

    Authors: Chih-Chiang Chien, Jhi-Joung Wang, Yih-Min Sun, Ding-Ping Sun, Ming-Jen Sheu, Shih-Feng Weng, Chin-Chen Chu, Hung-An Chen, Chung-Ching Chio, Jyh-Chang Hwang, Yi-Hua Lu, Hsien-Yi Wang and Wei-Chih Kan
    Citation: BMC Nephrology 2012 13:43
  22. The Chronic Kidney Disease Epidemiology Collaboration equation for estimation of glomerular filtration rate (eGFRCKD-EPI) improves GFR estimation compared with the Modification of Diet in Renal Disease Study equa...

    Authors: Tariq Shafi, Kunihiro Matsushita, Elizabeth Selvin, Yingying Sang, Brad C Astor, Lesley A Inker and Josef Coresh
    Citation: BMC Nephrology 2012 13:42
  23. The aim of the study was to determine whether distance between residence and peritoneal dialysis (PD) unit influenced peritonitis occurrence, microbiology, treatment and outcomes.

    Authors: Yeoungjee Cho, Sunil V Badve, Carmel M Hawley, Stephen P McDonald, Fiona G Brown, Neil Boudville M, Kathryn J Wiggins, Kym M Bannister, Philip Clayton and David W Johnson
    Citation: BMC Nephrology 2012 13:41
  24. Anaemia of chronic kidney disease increases the risk of death and adverse events, but can be managed using erythropoiesis stimulating agents (ESAs). However, recent evidence suggests that targeting a higher ha...

    Authors: Lawrence P McMahon, Michael X Cai, Sanjeev Baweja, Stephen G Holt, Annette B Kent, Vlado Perkovic, Murray J Leikis and Gavin J Becker
    Citation: BMC Nephrology 2012 13:40
  25. It is well known that the quality of life of patients with chronic kidney disease can be improved by dialysis. While previous studies have used retrospective designs and adhered to a standard target prescribed...

    Authors: Jin-Bor Chen, King-Kwan Lam, Yu-Jen Su, Wen-Chin Lee, Ben-Chung Cheng, Chien-Chun Kuo, Chien-Hsing Wu, Eton Lin, Yi-Chun Wang, Te-Chuan Chen and Shang-Chih Liao
    Citation: BMC Nephrology 2012 13:39
  26. Conditions associated with high intraglomerular filtration pressure can cause secondary focal segmental glomerulosclerosis (FSGS). Unilateral renal artery stenosis (RAS) or its occlusion results in FSGS-like c...

    Authors: Daiki Iwami, Hiroshi Harada, Hiroaki Usubuchi, Kiyohiko Hotta, Toshimori Seki, Masaki Togashi and Yuichiro Fukasawa
    Citation: BMC Nephrology 2012 13:38
  27. Moderate to severe renal insufficiency and albuminuria have been shown to be independent risk factors for atherosclerosis. However, little is known about the direct association between subclinical atherosclero...

    Authors: XiangLei Kong, XiaoYan Jia, Yong Wei, MeiYu Cui, ZunSong Wang, LiJun Tang, WenBin Li, ZhuXian Zhu, Ping Chen and DongMei Xu
    Citation: BMC Nephrology 2012 13:37
  28. High salt intake in patients with chronic kidney disease (CKD) may cause high blood pressure and increased albuminuria. Although, the estimation of salt intake is essential, there are no easy methods to estima...

    Authors: Makoto Ogura, Ai Kimura, Koki Takane, Masatsugu Nakao, Akihiko Hamaguchi, Hiroyuki Terawaki and Tatsuo Hosoya
    Citation: BMC Nephrology 2012 13:36
  29. Peritoneal dialysis-associated peritonitis (PD-peritonitis) due to Mycobacterium spp is uncommon. Non-tuberculous Mycobacterium (NTB) PD-peritonitis can present in a similar fashion to more common causes of bacte...

    Authors: Simon H Jiang, Darren M Roberts, Andrew H Dawson and Meg Jardine
    Citation: BMC Nephrology 2012 13:35
  30. Interventional diagnostic procedures are established for several diseases in medicine. Despite the KDOQI guideline recommendation for histological diagnosis of kidney disease to enable risk stratification, its...

    Authors: Dominik G Haider, Alexander Friedl, Slobodan Peric, Günther F Wiesinger, Michael Wolzt, Julian Prosenz, Henrik Fischer, Walter H Hörl, Afschin Soleiman and Valentin Fuhrmann
    Citation: BMC Nephrology 2012 13:34
  31. Antineutrophil cytoplasmic antibody (ANCA)-associated crescentic glomerulonephritis (CGN) is a major cause of rapidly progressive glomerulonephritis (RPGN). ANCA-associated CGN is generally classified into pau...

    Authors: Ryuji Morizane, Konosuke Konishi, Akinori Hashiguchi, Hirobumi Tokuyama, Shu Wakino, Hiroshi Kawabe, Matsuhiko Hayashi, Koichi Hayashi and Hiroshi Itoh
    Citation: BMC Nephrology 2012 13:32
  32. In survival analysis, patients on peritoneal dialysis are confronted with three different outcomes: transfer to hemodialysis, renal transplantation, or death. The Kaplan-Meier method takes into account one eve...

    Authors: Jean-Baptiste Beuscart, Dominique Pagniez, Eric Boulanger, Celia Lessore de Sainte Foy, Julia Salleron, Luc Frimat and Alain Duhamel
    Citation: BMC Nephrology 2012 13:31
  33. Elderly dialysis patients are prone to disabilities and functional decline. This aggravates their last period of life. It would be valuable to be able to preserve daily function and quality of life. Identifica...

    Authors: Juliette L Parlevliet, Bianca M Buurman, Marja M Hodac Pannekeet, Els M Boeschoten, Lucia ten Brinke, Marije E Hamaker, Barbara C van Munster and Sophia E de Rooij
    Citation: BMC Nephrology 2012 13:30
  34. Several renal histopathological features, including mesangial hypercellularity, glomerulosclerosis, tubular atrophy and interstitial fibrosis, are considered to be independent predictors of end-stage renal fai...

    Authors: Yanhong Li, Jian Wang, Xueming Zhu, Qihua Feng, Xiaozhong Li and Xing Feng
    Citation: BMC Nephrology 2012 13:29
  35. Home hemodialysis is common in New Zealand and associated with lower cost, improved survival and better patient experience. We present the case of a fully trained home hemodialysis patient who exsanguinated at...

    Authors: Kerryanne Allcock, Balaji Jagannathan, Christopher J Hood and Mark R Marshall
    Citation: BMC Nephrology 2012 13:28
  36. Microdeletions on chromosome 17q12 cause of diverse spectrum of disorders and have only recently been identified as a rare cause of Mayer-Rokitansky-Kuester-Hauser-Syndrome (MRKH), which is characterized by ut...

    Authors: Bernward Hinkes, Karl F Hilgers, Hanno J Bolz, Margarete Goppelt-Struebe, Kerstin Amann, Sandra Nagl, Carsten Bergmann, Wolfgang Rascher, Kai-Uwe Eckardt and Johannes Jacobi
    Citation: BMC Nephrology 2012 13:27
  37. Ethnic differences in the association between central obesity and raised albumin-creatinine ratio (ACR) have not been investigated. Our aim was to determine whether the association between central obesity, def...

    Authors: Irene GM van Valkengoed, Charles Agyemang, Ray T Krediet and Karien Stronks
    Citation: BMC Nephrology 2012 13:26
  38. Chronic kidney disease (CKD) is a major worldwide health problem. However, its burden among adolescents and young adults is unknown, especially in sub-Saharan Africa. The aim of this study was to investigate i...

    Authors: Justine B Bukabau, Jean-Robert R Makulo, Nestor M Pakasa, Eric P Cohen, François B Lepira, Patrick K Kayembe, Nazaire M Nseka and Ernest K Sumaili
    Citation: BMC Nephrology 2012 13:24
  39. The main function of the kidneys is to remove waste products and excess water from the blood. Loss of kidney function leads to various health issues, such as anemia, high blood pressure, bone disease, disorder...

    Authors: Sanjay Kr Singh, Adeel Malik, Ahmad Firoz and Vivekanand Jha
    Citation: BMC Nephrology 2012 13:23
  40. Dual renin-angiotensin system blockade with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers has been advocated to minimize proteinuria. However, recent trials have questioned the ren...

    Authors: Beatriz Fernandez-Fernandez, Alberto Ortiz, Carmen Gomez-Guerrero, Antonio Barat, Catalina Martín-Cleary and Jesús Egido
    Citation: BMC Nephrology 2012 13:21
  41. Fibroblast growth factor 23 (FGF23) has emerged as a risk factor for cardiovascular disease and mortality throughout all stages of chronic kidney disease (CKD), independent from established risk factors and ma...

    Authors: Marc G Vervloet, Arjan D van Zuilen, Annemieke C Heijboer, Piet M ter Wee, Michiel L Bots, Peter J Blankestijn and Jack FM Wetzels
    Citation: BMC Nephrology 2012 13:20
  42. Only a few large-scale studies have investigated the association between health-related quality of life (HRQOL) and renal function. Moreover, the HRQOL of patients with moderate renal dysfunction is frequently...

    Authors: Hajeong Lee, Yun Jung Oh, Myounghee Kim, Ho Kim, Jung Pyo Lee, Sejoong Kim, Kook-Hwan Oh, Ho Jun Chin, Kwon Wook Joo, Chun Soo Lim, Suhnggwon Kim, Yon Su Kim and Dong Ki Kim
    Citation: BMC Nephrology 2012 13:19
  43. Deceased donor kidneys are a scarce health resource, yet patient preferences for organ allocation are largely unknown. The aim of this study was to determine patient preferences for how kidneys should be alloc...

    Authors: Allison Tong, Stephen Jan, Germaine Wong, Jonathan C Craig, Michelle Irving, Steve Chadban, Alan Cass, Niamh Marren and Kirsten Howard
    Citation: BMC Nephrology 2012 13:18
  44. A large proportion of patients with autosomal dominant polycystic kidney disease (ADPKD) suffers from polycystic liver disease. Symptoms arise when liver volume increases. The somatostatin analogue lanreotide ...

    Authors: Tom JG Gevers, Melissa Chrispijn, Jack FM Wetzels and Joost PH Drenth
    Citation: BMC Nephrology 2012 13:17
  45. As several studies have shown an association between periodontal disease and chronic kidney disease (CKD), regular dental care may be an important strategy for reducing the burden of CKD. Access to dental care...

    Authors: Vanessa Grubbs, Laura C Plantinga, Delphine S Tuot and Neil R Powe
    Citation: BMC Nephrology 2012 13:16
  46. Dysregulation of the expression/shuttling of the aquaporin-2 water channel (AQP2) and the epithelial sodium channel (ENaC) in renal collecting duct principal cells has been found in animal models of hypertensi...

    Authors: Carolina Cannillo Graffe, Jesper Nørgaard Bech, Thomas Guldager Lauridsen, Henrik Vase and Erling Bjerregaard Pedersen
    Citation: BMC Nephrology 2012 13:15
  47. Catalase is an important antioxidant enzyme that regulates the level of intracellular hydrogen peroxide and hydroxyl radicals. The effects of catalase deficiency on albuminuria and progressive glomeruloscleros...

    Authors: Keiichi Takiue, Hitoshi Sugiyama, Tatsuyuki Inoue, Hiroshi Morinaga, Yoko Kikumoto, Masashi Kitagawa, Shinji Kitamura, Yohei Maeshima, Da-Hong Wang, Noriyoshi Masuoka, Keiki Ogino and Hirofumi Makino
    Citation: BMC Nephrology 2012 13:14
  48. This study examines the patients' need for information and guidance in the selection of dialysis modality, and in establishing and practicing home dialysis. The study focuses on patients' experiences living wi...

    Authors: Ellen Rygh, Eli Arild, Elin Johnsen and Markus Rumpsfeld
    Citation: BMC Nephrology 2012 13:13

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