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  1. Dual renin-angiotensin system blockade with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers has been advocated to minimize proteinuria. However, recent trials have questioned the ren...

    Authors: Beatriz Fernandez-Fernandez, Alberto Ortiz, Carmen Gomez-Guerrero, Antonio Barat, Catalina Martín-Cleary and Jesús Egido
    Citation: BMC Nephrology 2012 13:21
    Content type: Case report Published on:

  2. Fibroblast growth factor 23 (FGF23) has emerged as a risk factor for cardiovascular disease and mortality throughout all stages of chronic kidney disease (CKD), independent from established risk factors and ma...

    Authors: Marc G Vervloet, Arjan D van Zuilen, Annemieke C Heijboer, Piet M ter Wee, Michiel L Bots, Peter J Blankestijn and Jack FM Wetzels
    Citation: BMC Nephrology 2012 13:20
    Content type: Research article Published on:

  3. Only a few large-scale studies have investigated the association between health-related quality of life (HRQOL) and renal function. Moreover, the HRQOL of patients with moderate renal dysfunction is frequently...

    Authors: Hajeong Lee, Yun Jung Oh, Myounghee Kim, Ho Kim, Jung Pyo Lee, Sejoong Kim, Kook-Hwan Oh, Ho Jun Chin, Kwon Wook Joo, Chun Soo Lim, Suhnggwon Kim, Yon Su Kim and Dong Ki Kim
    Citation: BMC Nephrology 2012 13:19
    Content type: Research article Published on:

  4. Deceased donor kidneys are a scarce health resource, yet patient preferences for organ allocation are largely unknown. The aim of this study was to determine patient preferences for how kidneys should be alloc...

    Authors: Allison Tong, Stephen Jan, Germaine Wong, Jonathan C Craig, Michelle Irving, Steve Chadban, Alan Cass, Niamh Marren and Kirsten Howard
    Citation: BMC Nephrology 2012 13:18
    Content type: Research article Published on:

  5. A large proportion of patients with autosomal dominant polycystic kidney disease (ADPKD) suffers from polycystic liver disease. Symptoms arise when liver volume increases. The somatostatin analogue lanreotide ...

    Authors: Tom JG Gevers, Melissa Chrispijn, Jack FM Wetzels and Joost PH Drenth
    Citation: BMC Nephrology 2012 13:17
    Content type: Study protocol Published on:

  6. As several studies have shown an association between periodontal disease and chronic kidney disease (CKD), regular dental care may be an important strategy for reducing the burden of CKD. Access to dental care...

    Authors: Vanessa Grubbs, Laura C Plantinga, Delphine S Tuot and Neil R Powe
    Citation: BMC Nephrology 2012 13:16
    Content type: Research article Published on:

  7. Dysregulation of the expression/shuttling of the aquaporin-2 water channel (AQP2) and the epithelial sodium channel (ENaC) in renal collecting duct principal cells has been found in animal models of hypertensi...

    Authors: Carolina Cannillo Graffe, Jesper Nørgaard Bech, Thomas Guldager Lauridsen, Henrik Vase and Erling Bjerregaard Pedersen
    Citation: BMC Nephrology 2012 13:15
    Content type: Research article Published on:

  8. Catalase is an important antioxidant enzyme that regulates the level of intracellular hydrogen peroxide and hydroxyl radicals. The effects of catalase deficiency on albuminuria and progressive glomeruloscleros...

    Authors: Keiichi Takiue, Hitoshi Sugiyama, Tatsuyuki Inoue, Hiroshi Morinaga, Yoko Kikumoto, Masashi Kitagawa, Shinji Kitamura, Yohei Maeshima, Da-Hong Wang, Noriyoshi Masuoka, Keiki Ogino and Hirofumi Makino
    Citation: BMC Nephrology 2012 13:14
    Content type: Research article Published on:

  9. This study examines the patients' need for information and guidance in the selection of dialysis modality, and in establishing and practicing home dialysis. The study focuses on patients' experiences living wi...

    Authors: Ellen Rygh, Eli Arild, Elin Johnsen and Markus Rumpsfeld
    Citation: BMC Nephrology 2012 13:13
    Content type: Research article Published on:

  11. The nephron number is thought to be associated with the outcome of chronic kidney disease (CKD). If the nephron number can be estimated in the clinical setting, it could become a strong tool to predict renal o...

    Authors: Toshiyuki Imasawa, Takashi Nakazato, Hiroo Ikehira, Hiroyuki Fujikawa, Ryo Nakajima, Takahito Ito, Yutaka Ando, Mitsuhiro Yoshimura, Masaru Nakayama, Kensei Yahata, Osamu Sasaki, Takaaki Yaomura, Ritsuko Katafuchi, Tsuyoshi Yamamura, Takehiko Kawaguchi, Motonobu Nishimura…
    Citation: BMC Nephrology 2012 13:11
    Content type: Study protocol Published on:

  12. There are no national data on the magnitude and pattern of chronic kidney disease (CKD) in India. The Indian CKD Registry documents the demographics, etiological spectrum, practice patterns, variations and spe...

    Authors: Mohan M Rajapurkar, George T John, Ashok L Kirpalani, Georgi Abraham, Sanjay K Agarwal, Alan F Almeida, Sishir Gang, Amit Gupta, Gopesh Modi, Dilip Pahari, Ramdas Pisharody, Jai Prakash, Anuradha Raman, Devinder S Rana, Raj K Sharma, RN Sahoo…
    Citation: BMC Nephrology 2012 13:10
    Content type: Research article Published on:

  13. MELAS syndrome (MIM ID#540000), an acronym for Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-like episodes, is a genetically heterogeneous mitochondrial disorder with protean manifestations and occa...

    Authors: Giorgina Barbara Piccoli, Laura Davico Bonino, Paola Campisi, Federica Neve Vigotti, Martina Ferraresi, Federica Fassio, Isabelle Brocheriou, Francesco Porpiglia and Gabriella Restagno
    Citation: BMC Nephrology 2012 13:9
    Content type: Case report Published on:

  14. Neutrophil gelatinase associated lipocalin (NGAL) is a biomarker of kidney injury. We examined plasma levels of NGAL in a cohort of 57 kidney allograft recipients (Tx group, 39 ± 13 years), a uraemic group of ...

    Authors: Nils E Magnusson, Mads Hornum, Kaj Anker Jørgensen, Jesper Melchior Hansen, Claus Bistrup, Bo Feldt-Rasmussen and Allan Flyvbjerg
    Citation: BMC Nephrology 2012 13:8
    Content type: Research article Published on:

  15. Chyluria is a medical condition with presence of chyle in the urine. The disease is most prevalent in endemic regions of Africa and the Indian subcontinent where it is mostly caused by parasitic infections, pa...

    Authors: Benjamin Knier, Beatrix Büschges-Seraphin, Karl F Hilgers, Kerstin U Amann, Michael Uder, Kai-Uwe Eckardt and Johannes Jacobi
    Citation: BMC Nephrology 2012 13:7
    Content type: Case report Published on:

  16. Urea transporter UT-B is the major urea transporter in erythrocytes and the descending vasa recta in the kidney. In this study, we investigated the effects of long-term UT-B deficiency on functional and struct...

    Authors: Lei Zhou, Yan Meng, Tianluo Lei, Dan Zhao, Jing Su, Xuejian Zhao and Baoxue Yang
    Citation: BMC Nephrology 2012 13:6
    Content type: Research article Published on:

  17. Transfusion patterns are not well characterized in non-dialysis (ND) chronic kidney disease (CKD) patients. This study describes the proportion of patients transfused, units of blood transfused and trigger-hem...

    Authors: Kathleen M Fox, Jerry Yee, Ze Cong, John M Brooks, Jeffrey Petersen, Lois Lamerato and Shravanthi R Gandra
    Citation: BMC Nephrology 2012 13:5
    Content type: Research article Published on:

  18. Black individuals are far more likely than white individuals to develop end stage renal disease (ESRD). However, earlier stages of chronic kidney disease (CKD) have been reported to be less prevalent among bla...

    Authors: Pradeep Arora, Srini Rajagopalan, Nilang Patel, Neha Nainani, Rocco C Venuto and James W Lohr
    Citation: BMC Nephrology 2012 13:4
    Content type: Research article Published on:

  19. Increased left ventricular mass (LVM) is associated with adverse outcomes in patients receiving chronic hemodialysis. Among patients receiving conventional hemodialysis (CHD, 3×/week, 4 hrs/session), we evalua...

    Authors: Ron Wald, Andrew T Yan, Jeffrey Perl, Depeng Jiang, M Sandra Donnelly, Howard Leong-Poi, Philip A McFarlane, Jordan J Weinstein and Marc B Goldstein
    Citation: BMC Nephrology 2012 13:3
    Content type: Research article Published on:

  20. The aim of this study was to explore the associations between common potential functional promoter polymorphisms in pro-/anti-inflammatory cytokine genes and kidney function/chronic kidney disease (CKD) preval...

    Authors: Rieko Okada, Kenji Wakai, Mariko Naito, Emi Morita, Sayo Kawai, Nobuyuki Hamajima, Megumi Hara, Naoyuki Takashima, Sadao Suzuki, Toshiro Takezaki, Keizo Ohnaka, Kokichi Arisawa, Hiroshi Hirohata, Keitaro Matsuo, Haruo Mikami, Michiaki Kubo…
    Citation: BMC Nephrology 2012 13:2
    Content type: Research article Published on:

  21. Recently, the Kidney Disease: Improving Global Outcomes (KDIGO) group recommended that patients with CKD should be assigned to stages and composite relative risk groups according to GFR (G) and proteinuria (A)...

    Authors: Chagriya Kitiyakara, Sukit Yamwong, Prin Vathesatogkit, Anchalee Chittamma, Sayan Cheepudomwit, Somlak Vanavanan, Bunlue Hengprasith and Piyamitr Sritara
    Citation: BMC Nephrology 2012 13:1
    Content type: Research article Published on:

  22. Acute renal failure (ARF) is an important clinical problem with a high mortality and morbidity. One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are tho...

    Authors: Najah R Hadi, Fadhil G Al-amran and Ayad A Hussein
    Citation: BMC Nephrology 2011 12:70
    Content type: Research article Published on:

  23. On dialysis, survival among patients with diabetes mellitus is inferior to survival of non-diabetic patients. We hypothesized that patients with diabetes as primary renal disease have worse survival compared t...

    Authors: Marielle A Schroijen, Olaf M Dekkers, Diana C Grootendorst, Marlies Noordzij, Johannes A Romijn, Raymond T Krediet, Elisabeth W Boeschoten and Friedo W Dekker
    Citation: BMC Nephrology 2011 12:69
    Content type: Research article Published on:

  24. Acute pyelonephritis (APN) is differently defined according to imaging or clinical criteria. In adults information on the relationship between imaging and clinical data is lacking.

    Authors: Giorgina Barbara Piccoli, Valentina Consiglio, Maria Chiara Deagostini, Melania Serra, Marilisa Biolcati, Francesca Ragni, Alberto Biglino, Agostino De Pascale, Mauro Felice Frascisco, Andrea Veltri and Francesco Porpiglia
    Citation: BMC Nephrology 2011 12:68
    Content type: Research article Published on:

  25. High-dose erythropoiesis-stimulating agents (ESA) for anemia of chronic kidney disease (CKD) have been associated with adverse clinical outcomes and do not always improve erythropoiesis. We hypothesized that h...

    Authors: Jula K Inrig, Suzanne K Bryskin, Uptal D Patel, Murat Arcasoy and Lynda A Szczech
    Citation: BMC Nephrology 2011 12:67
    Content type: Research article Published on:

  26. The purpose of our study was to determine characteristics that influence the utilization of non-conventional hemodialysis (NCHD) therapies and its subtypes (nocturnal (NHD), short daily (SDHD), long convention...

    Authors: Nathan Allen, Daniel Schwartz, Paul Komenda, Robert P Pauly, Deborah Zimmerman, Gemini Tanna, Jeffery Schiff, Claudio Rigatto and Manish M Sood
    Citation: BMC Nephrology 2011 12:66
    Content type: Research article Published on:

  28. Glomerular damage in IgA nephropathy (IgAN) is mediated by complement activation via the alternative and lectin pathways. Therefore, we focused on molecules stabilizing and regulating the alternative pathway C...

    Authors: Kisara Onda, Isao Ohsawa, Hiroyuki Ohi, Mariko Tamano, Satoshi Mano, Michiro Wakabayashi, Akie Toki, Satoshi Horikoshi, Teizo Fujita and Yasuhiko Tomino
    Citation: BMC Nephrology 2011 12:64
    Content type: Research article Published on:

  29. For chronic hemodialysis, the ideal permanent vascular access is the arteriovenous fistula (AVF). Temporary catheters should be reserved for acute dialysis needs. The AVF is associated with lower infection rat...

    Authors: Gisele MS Bonfante, Isabel C Gomes, Eli Iola G Andrade, Eleonora M Lima, Francisco A Acurcio and Mariângela L Cherchiglia
    Citation: BMC Nephrology 2011 12:63
    Content type: Research article Published on:

  31. Ozonated autohemotherapy (OA) has been previously successfully used in the treatment of patients affected by peripheral occlusive arterial disease. OA consists of an intrafemoral reinfusion of autologous blood...

    Authors: Chiara Foglieni, Alessandro Fulgenzi, Daniela Belloni, Clara Sciorati, Elisabetta Ferrero and Maria Elena Ferrero
    Citation: BMC Nephrology 2011 12:61
    Content type: Research article Published on:

  32. Single nucleotide polymorphisms (SNPs) are the most common forms of sequence variations in the human genome. They contribute to the human phenotypic spectrum and are associated with variations in response to p...

    Authors: Ashwini Raghavendra, Annes Siji, TS Sridhar, Kishore Phadke and Anil Vasudevan
    Citation: BMC Nephrology 2011 12:60
    Content type: Research article Published on:

  33. We sought to investigate the relationships among the plasma levels of carotenoids, tocopherols, endogenous antioxidants, oxidative damage and lipid profiles and their possible effects on the cardiovascular ris...

    Authors: Miguel Roehrs, Juliana Valentini, Clóvis Paniz, Angela Moro, Mariele Charão, Rachel Bulcão, Fernando Freitas, Natália Brucker, Marta Duarte, Mirna Leal, Geni Burg, Tilman Grune and Solange Cristina Garcia
    Citation: BMC Nephrology 2011 12:59
    Content type: Research article Published on:

  34. Intradialytic hypotension may adversely affect the outcome of chronic hemodialysis. Therapeutic albumin has powerful anti-oxidant and anti-inflammatory properties. We have recently shown that systematic colloi...

    Authors: Guy Rostoker, Mireille Griuncelli, Christelle Loridon, Thomas Bourlet, Eric Illouz and Abbes Benmaadi
    Citation: BMC Nephrology 2011 12:58
    Content type: Research article Published on:

  35. Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disorder. It is characterized by focal development and progressive enlargement of renal cysts leading to end-stage rena...

    Authors: Stanislas Bataille, Yvon Berland, Michel Fontes and Stéphane Burtey
    Citation: BMC Nephrology 2011 12:57
    Content type: Research article Published on:

  36. Vascular calcification has been recognized as a risk factor for cardiovascular (CV) events in patients with end-stage renal disease (ESRD). However, the association of carotid artery calcification (CAAC) with ...

    Authors: Masaru Nakayama, Yoriko Ura, Masaharu Nagata, Yasushi Okada, Yoko Sumida, Kanako Nishida, Hirofumi Ikeda and Yoshiki Kaizu
    Citation: BMC Nephrology 2011 12:56
    Content type: Research article Published on:

  37. Aluminium (Al) toxicity was frequent in the 1980s in patients ingesting Al containing phosphate binders (Alucaps) whilst having HD using water potentially contaminated with Al. The aim of this study was to det...

    Authors: Ruth Pepper, Neil Campbell, Magdi M Yaqoob, Norman B Roberts and Stanley L-S Fan
    Citation: BMC Nephrology 2011 12:55
    Content type: Research article Published on:

  38. There is a perception that kidney transplant recipients transferred from pediatric centers to adult care have an increased risk of graft loss. It is not clear whether young adults transplanted in adult centers...

    Authors: James A Kiberd, Phil Acott and Bryce A Kiberd
    Citation: BMC Nephrology 2011 12:54
    Content type: Research article Published on:

  39. To obtain information on cardiovascular morbidity, hypertension control, anemia and mineral metabolism based on the analysis of the baseline characteristics of a large cohort of Spanish patients enrolled in an...

    Authors: Alberto Martínez-Castelao, José L Górriz, José M Portolés, Fernando De Alvaro, Aleix Cases, José Luño, Juan F Navarro-González, Rafael Montes, Juan J De la Cruz-Troca, Aparna Natarajan and Daniel Batlle
    Citation: BMC Nephrology 2011 12:53
    Content type: Research article Published on:

  40. Renal sinus fat may mediate obesity-related vascular disease, although this fat depot has not been assessed in a community-based sample. We sought to develop a protocol to quantify renal sinus fat accumulation...

    Authors: Meredith C Foster, Shih-Jen Hwang, Stacy A Porter, Joseph M Massaro, Udo Hoffmann and Caroline S Fox
    Citation: BMC Nephrology 2011 12:52
    Content type: Technical advance Published on:

  41. Nightly extended hours hemodialysis may improve left ventricular hypertrophy and function and endothelial function but presents problems of sustainability and increased cost. The effect of alternate nightly ho...

    Authors: Carolyn L van Eps, Leanne Jeffriess, Brian Haluska, Carmel M Hawley, Jeffrey Coombes, Aya Matsumoto, Janine K Jeffries, David W Johnson, Scott B Campbell, Nicole M Isbel, David W Mudge and Thomas Marwick
    Citation: BMC Nephrology 2011 12:51
    Content type: Research article Published on:

  42. Haemodialysis is the most common form of renal replacement therapy in Nigeria. The high cost of haemodialysis has made optimal therapy of end-stage renal disease difficult in Nigeria. This paper is a review of...

    Authors: Udeme E Ekrikpo, Aniema I Udo, Enobong E Ikpeme and Emmanuel E Effa
    Citation: BMC Nephrology 2011 12:50
    Content type: Research article Published on:

  43. Lanthanum carbonate (FOSRENOL®) is an effective, well-tolerated phosphate binder. The ability of lanthanum to reduce serum phosphorus levels to ≤5.5 mg/dL in patients with end-stage renal disease (ESRD) was asses...

    Authors: Nirupama Vemuri, Michael F Michelis and Albert Matalon
    Citation: BMC Nephrology 2011 12:49
    Content type: Research article Published on:

  44. Intracystic infection, in Autosomal Dominant Polycystic Kidney Disease (ADPKD) and in kidneys with multiple cysts, is a diagnostic and therapeutic challenge, as conventional imaging techniques may not discrimi...

    Authors: Giorgina B Piccoli, Vincenzo Arena, Valentina Consiglio, Maria Chiara Deagostini, Ettore Pelosi, Anastasios Douroukas, Daniele Penna and Giancarlo Cortese
    Citation: BMC Nephrology 2011 12:48
    Content type: Research article Published on:

  45. Although chronic kidney disease (CKD) disproportionately affects older adults, they are less likely to be referred to a nephrologist. Factors that influence the referral decisions of primary care providers (PC...

    Authors: Kellie H Campbell, Sandy G Smith, Joshua Hemmerich, Nicole Stankus, Chester Fox, James W Mold, Ann M O'Hare, Marshall H Chin and William Dale
    Citation: BMC Nephrology 2011 12:47
    Content type: Research article Published on:

  46. Warfarin nomograms to guide dosing have been shown to improve control of the international normalized ratio (INR) in the general outpatient setting. However, the effectiveness of these nomograms in hemodialysi...

    Authors: Benjamin KA Thomson, Jennifer M MacRae, Lianne Barnieh, Jianguo Zhang, Elizabeth MacKay, Megan A Manning and Brenda R Hemmelgarn
    Citation: BMC Nephrology 2011 12:46
    Content type: Research article Published on:

  47. Knowing the risk factors of CKD should be able to identify at risk populations. We thus aimed to develop and validate a simplified clinical prediction score capable of indicating those at risk.

    Authors: Ammarin Thakkinstian, Atiporn Ingsathit, Amnart Chaiprasert, Sasivimol Rattanasiri, Pornpen Sangthawan, Pongsathorn Gojaseni, Kriwiporn Kiattisunthorn, Leena Ongaiyooth and Prapaipim Thirakhupt
    Citation: BMC Nephrology 2011 12:45
    Content type: Research article Published on:

  48. Patients with chronic kidney disease (CKD) are less likely to receive cardiovascular medications. It is unclear whether differential cardiovascular drug use explains, in part, the excess risk of cardiovascular...

    Authors: Nisha Bansal, Chi-yuan Hsu, Malini Chandra, Carlos Iribarren, Stephen P Fortmann, Mark A Hlatky and Alan S Go
    Citation: BMC Nephrology 2011 12:44
    Content type: Research article Published on:

  49. Despite the substantial progress in the quality of critical care, the incidence and mortality of acute kidney injury (AKI) continues to rise during hospital admissions. We conducted a national, multicenter, pr...

    Authors: Laszlo Medve, Csaba Antek, Balazs Paloczi, Szilvia Kocsi, Bela Gartner, Zsuzsanna Marjanek, Gabor Bencsik, Peter Kanizsai and Tibor Gondos
    Citation: BMC Nephrology 2011 12:43
    Content type: Research article Published on:

  50. Chronic Kidney Disease is a major public health problem worldwide with enormous cost burdens on health care systems in developing countries. We aimed to provide a detailed analysis of the processes and costs o...

    Authors: Priyanga Ranasinghe, Yashasvi S Perera, Mohamed FM Makarim, Aruna Wijesinghe and Kamani Wanigasuriya
    Citation: BMC Nephrology 2011 12:42
    Content type: Research article Published on:
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BMC Nephrology

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